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. Author manuscript; available in PMC: 2011 Sep 7.
Published in final edited form as: Nature. 2010 Aug 25;467(7315):562–566. doi: 10.1038/nature09321

Figure 4.

Figure 4

The Widom 601 sequence forms a 145 bp nucleosome core particle. (a) Superposition of 601 nucleosome core particle DNA (in blue) and human αsatellite nucleosome core particle DNA (peach) in simplified cartoon representation. The major differences between the two DNA structures at SHL +5 and −5 are highlighted in red and green respectively. (b) and (c) Superpositions of the two DNA structures at SHL +5 and −5 respectively. Numbers shown are the base positions from the nucleosome dyad. (d) Alignment of DNA present in nucleosome core particle crystal structures shows 5 bp major and minor grooves blocks. The 5 or 6 bp major groove blocks at SHL ±2 and ±5 accommodates differences in the DNA structures (red arrows). DNA dyad indicated by black arrow. Human α-satellite sequence alignments based on Fig.1 of Ong et al13.