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. Author manuscript; available in PMC: 2011 Sep 7.
Published in final edited form as: Nature. 2010 Aug 25;467(7315):562–566. doi: 10.1038/nature09321

Figure 5.

Figure 5

Model for Ran-RCC1-nucleosome core particle complex assuming no conformational changes. Ran (light blue) was modeled by aligning the RCC1 component of the Ran-RCC1 complex crystal structure (PDB id 1I2M) with one of the RCC1 subunits in the RCC1-nucleosome core particle structure. The flexible C-terminus of Ran is shown in white. The GDP nucleotide (magenta) was modeled using the nucleotide present in the RanGDP structure (PDB id 3GJ0). If Ran interacts with histones in the Ran-RCC1-nucleosome complex, a conformational change in either RCC1 or Ran presumably must occur.