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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Arthritis Rheum. 2011 Sep;63(9):2764–2773. doi: 10.1002/art.30424

Figure 2.

Figure 2

Plasma immunoglobulins and antibody levels detected in SLE-DKO and ND-DKO mice at 4–8 weeks post engraftment. A. Plasma IgG levels, representing all SLE-DKO and ND-DKO derived from P1-5 and N1-4 donors. B. Anti-dsDNA antibody, in humanized SLE and ND DKO mice. There were 1–7 mice/group tested from SLE-DKO and ND-DKO derived from P1-5 and N1-4 donors. There was no significant difference (P< 0.26) between the 2 groups. The 2 highest values were from SLE-DKO mice engrafted with P1 and P5 donors. C. Anti-CL (GCL) in SLE-DKO, and ND-DKO mice. SLE-DKO mice from donor P5 (APS) and P1, 2, and 4 were presented. aCL levels of P1, 2, and 4 SLE-DKO mice were similar to ND-DKO mice. P5-DKO vs. ND-DKO: P< 0.017; P5-DKO vs. SLE (P1, 2, 4)–DKO: P<0.01; SLE (P1, 2, 4) -DKO vs. DKO (no engraftment): P< 0.22; ND-DKO vs. DKO: P<0.9. Each point represents 1 mouse in all the graphs. Elevated ACL levels were demonstrated in all 7 P5-DKO mice at 2–3 different time points within 2–4 weeks post engraftment.