TABLE III.
Summary of Studies Reporting Aggressive Behaviors in Individuals With Rare CNVs
| CNV | Ascertainment | Total cases | (+) Aggressive and/or impulsive behavior | Study |
|---|---|---|---|---|
| 15q13.3 (del) | Developmental delay, epilepsya | 10 | 1 | Shinawi et al. [2009] |
| 15q13.3 (del) | Developmental delay, epilepsy, autism spectrum disorder | 5 | 5 | Miller et al. [2009] |
| 15q13.3 (del) | Developmental delay, autism spectrum disorderb | 14 | 9 | van Bon et al. [2009] |
| 1q21.1 (del) | Congenital heart defects, developmental delay, schizophreniac | 21 | 1 | Brunetti-Pierri et al. [2008] |
| 16p13.1 (del/dup) | Intellectual disability, multiple congenital abnormalities | 13 | 4 | Hannes et al. [2009] |
| 16p13.1 (del/dup) | Intellectual disability, autism | 7 | 2 | Ullmann et al. [2007] |
a
Ten individuals from four unrelated families.
b
Fourteen children from 12 unrelated families.
c
Two probands also described to have behavioral problems.