Fig. 6.

Quantification of histological OA characteristics in knee joints of female and male WT and TTD mice, aged 52 and 104 weeks. a Cartilage damage, scoring was performed according to the OARSI Working Group scoring system. b proteoglycan loss. The staining score is inversely correlated with of the Safranin O staining intensity, a high score therefore indicates more proteoglycan loss. c Osteophyte presence at the medial tibia, a higher score meaning more mature (mineralized) osteophytes. Shown are averages ±SEM, significance was tested within genders, with p < 0.05 considered significant. Ages are depicted inside the bars. n.p. not present