Fig. 2.

Representative region of interest (ROI) drawings of a prefrontal cortex (PFC; yellow scale bar = 1.5 mm) and b hippocampus (HPC; yellow scale bar = 3 mm) on co-registered anatomical T₁ and T₂ coronal images. c Baseline BOLD signal (T₂*-weighted signal intensity) for Good Spatial Performers (GSP; black bar) and Poor Spatial Performers (PSP; white bar) in the PFC and HPC of female rhesus macaques. d Total percentage BOLD signal change (T₂*-weighted signal intensity before and after scopolamine challenge; overall change in the brain regions analyzed) following scopolamine challenge in GSP and PSP. e Percentage change in BOLD signal (T₂*-weighted signal intensity) in the PFC and HPC of GSP and PSP. f Representative images of hippocampus ROI in baseline and scopolamine scans of a GSP and a PSP animal (black scale bar = 1.5 mm). Data are presented as group mean ± SEM. ** P < 0.01 compared to PSP