Fig. 1.

PDCs from aged subjects are impaired in their capacity to secrete IFN-I and IFN-III. Purified PDCs from aged and young subjects were stimulated with CPG or heat-killed influenza (Flu). Cytokine secretion was determined after overnight stimulation. a Bar diagram depicts the level of type I IFN secretion by aged and young PDCs. b Bar diagram depicts the level of type III IFN secretion by aged and young PDCs. c Bar diagrams depict the levels of TNF-α, IL-6, IL-10, and IP-10 secretion by aged and young PDCs. Figure is mean ±SE of 25 different aged and young subjects