Table 2.

Changes in cytokine profiles with age and after RSV treatment

Marker	Age		RSV treatment in old mice
	Intracellular	Extracellular	Intracellular	Extracellular
IL-2	↔	↓↓	↔	↑
FN-γ	↑	↑↑	↓	↓
IL-6	↔	↓	↓↓	↑
TNF-α	ND	↑	ND	↓
L-4	↔	↓↓	↓	↑
IL-5	↑a	ND	↓b	ND
IL-10	↑↑	↑↑	↓↓	↓

↔, no significant change

↑, <50% increase; P < 0.05 or P < 0.01

↑↑, >50% increase; P < 0.01

↓: <50% decrease; P < 0.05 or P < 0.01

↓↓: >50% decrease; P < 0.01

ND not determined

^aIn middle-aged mice

^bIn LT RSV middle-aged mice