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Example of the case that had invasive lesion in subsequent resection. ER/PR/HER2+ DCIS in initial biopsy: A. H&E stain; B. ER PharmDx stain and C. HercepTest stain. DCIS and invasive lesion in subsequent resection: D. H&E stain; E. ER PharmDx stain and F. HercepTest stain. Note the lack of ER and HER2 expression in the invasive element in subsequent resection.
