Table 4.

Univariate and Multivariable Models of Invasion

4A.	Univariate						Multivariable
	Total			Exclude vaccinated patients			Total			Exclude vaccinated patients
	Unadjusted Odds Ratio	95% CI	Wald p value	Unadjusted Odds Ratio	95% CI	Wald p value	Adjusted Odds Ratio	95% CI	Wald p value	Adjusted Odds Ratio	95% CI	Wald p value
HER2 Status
HER2+ vs. HER2−	4.01	1.73–9.34	0.001	3.99	1.47–10.82	0.007	4.15	1.56–11.04	0.004	3.43	0.98–12.02	0.06
ER Status
ER− vs. ER+	1.59	0.67–3.82	0.30	2.53	0.92–6.96	0.07	0.54	0.19–1.58	0.26	0.94	0.24–3.65	0.93
Grade
Intermediate vs.Low	1.79	0.20–16.12	0.15	1.54	0.17–14.28	0.44	2.26	0.24–21.61	0.36	1.84	0.19–18.07	0.75
High vs. Low	3.92	0.48–32.19		2.71	0.32–23.14		3.80	0.42–34.00		2.30	0.24–21.70

4B.	Univariate						Multivariable
	Total			Exclude vaccinated patients			Total			Exclude vaccinated patients
	Unadjusted Odds Ratio	95% CI	Wald p value	Unadjusted Odds Ratio	95% CI	Wald p value	Adjusted Odds Ratio	95% CI	Wald p value	Adjusted Odds Ratio	95% CI	Wald p value
Phenotype
ER/PR+/HER2−	1.00#		0.013	1.00#		0.05	1.00#		0.04	1.00#		0.19
ER/PR/HER2+	4.87	1.72–13.74		3.13	0.69–14.10		4.53	1.55–13.22		3.17	0.67–14.95
ER/PR−/HER2+	3.46	1.23–9.71		4.65	1.46–14.75		2.35	0.76–7.26		3.46	0.96–12.51
ER/PR/HER2−	1.22	0.13–11.18		1.22	0.13–11.18		0.94	0.10–8.93		1.06	0.11–10.23
Grade
Intermediate vs. Low	1.79	0.20–16.12	0.15	1.54	0.17–14.28	0.44	2.29	0.24–22.13	0.39	1.78	0.18–17.64	0.78
High vs. Low	3.92	0.48–32.19		2.71	0.32–23.14		3.69	0.41 0 33.22		2.18	0.23–20.52

^#Referent category