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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Eur J Neurosci. 2011 Aug 16;34(5):695–704. doi: 10.1111/j.1460-9568.2011.07799.x

Figure 3. Fostriecin block of phosphatase activity increases BK currents in β4 KO neurons.

Figure 3

(A) Example traces before (upper panel) and 10 minutes after application of BK channel blocker Paxilline (middle panel). Lower panel shows subtracted net BK current. (B) Example isolation of BK current from a Fostriecin treated cell. Vertical scale represents 1 nA current (vertical) and 10 ms time (horizontal). (C) Current density is summarized for BK current as a function of voltage. Filled symbols are for control, empty symbols are for Fostriecin-treated cells. Numbers in parentheses represent number of measured cells. (D) Activation time of isolated BK current is shorter with Fostriecin treatment. Inset shows example isolated BK current traces during first 5 millisecond of a +60 mV voltage step.