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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Eur J Neurosci. 2011 Aug 16;34(5):695–704. doi: 10.1111/j.1460-9568.2011.07799.x

Figure 6. cAMP reproduces effects of Fostriecin on action potential amplitude and half-width in KO neurons.

Figure 6

(A) Example action potential waveforms recorded from WT and β4 KO neurons during 210 pA current injection. The plots represent 10th action potentials from action potential trains of control (un-treated) neurons (solid gray line) and from neurons treated with 1 mM intracellular cAMP (solid dark line). Co-application of BK channel specific blocker 5 μM Paxilline with cAMP (dashed line) is also shown. Scale bars are 20 mV (for voltage axis) and 2 ms (for time axis). (B–D) Plots show averaged action potential properties including action potential amplitude (B), half-width (C) and fAHP amplitude (D). Data are shown for the 10th action potential during a 210 pA current injection. Taken from left, first columns represent control, second (middle) columns are for cAMP in the pipette (intracellular), third columns are for cAMP (pipette) and Paxilline in the bath solution.