CIA was induced in wild type (♦, n = 36), Crp−/− (○, n = 27), and CRPTg (●, n = 25) mice and arthritis symptoms were monitored for 50 days, as described in the Materials and Methods. Following initial clinical presentation, Crp−/− had the most rapid progression of disease, whereas disease was nearly static for CRPTg (A; see also Table 1). Furthermore compared to wild type mice, disease symptoms were significantly worse in Crp−/− (open bars) and significantly better for CRPTg (black bars) than for wild type (gray bars) (B and C). The results shown are from 3 separate experiments. *; p < 0.0001 for ANOVA and **; p < 0.0001 for PLSD tests.