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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Arthritis Rheum. 2011 Sep;63(9):2641–2650. doi: 10.1002/art.30444

Figure 4. CIA is exacerbated by targeted deletion of the mouse Crp gene and dampened by transgene-expressed human CRP.

Figure 4

CIA was induced in wild type (♦, n = 36), Crp−/− (○, n = 27), and CRPTg (●, n = 25) mice and arthritis symptoms were monitored for 50 days, as described in the Materials and Methods. Following initial clinical presentation, Crp−/− had the most rapid progression of disease, whereas disease was nearly static for CRPTg (A; see also Table 1). Furthermore compared to wild type mice, disease symptoms were significantly worse in Crp−/− (open bars) and significantly better for CRPTg (black bars) than for wild type (gray bars) (B and C). The results shown are from 3 separate experiments. *; p < 0.0001 for ANOVA and **; p < 0.0001 for PLSD tests.