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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Arthritis Rheum. 2011 Sep;63(9):2641–2650. doi: 10.1002/art.30444

Figure 5. Mouse Crp deletion and human CRP expression do not alter the anti-CII IgG response during CIA.

Figure 5

(A) Robust elevation of serum human CRP level (filled circle) was observed in CRPTg one day after initial immunization with CII and CFA (30-fold increase above baseline) and again one day following the booster injection (3.6-fold incrase), and levels of human CRP slowly returned to normal during the symptomatic phase. In comparison, in the same animals mouse CRP (open circle) was only modestly elevated. (B) Serum anti-CII IgG levels did not differ between Crp−/− (open circle), wild type (filled diamond), and CRPTg (filled circle).