. Author manuscript; available in PMC: 2012 Oct 1.

Published in final edited form as: Regul Toxicol Pharmacol. 2011 Jul 1;61(1):98–104. doi: 10.1016/j.yrtph.2011.06.006

Table 10.

Percentage of substances labeled as ocular irritants based on estimated underlying positive response rates for three strategies: three binomial distributions

Three Binomial Distributions	Estimated Underlying Positive Response Rate	Percentage of Substances That Would be Labeled as Ocular Irritants
Three Binomial Distributions	Estimated Underlying Positive Response Rate	Strategy 1 Current FHSA	Strategy 2 ≥1/3 Positive Animals	Strategy 3 ≥2/3 Positive Animals
Nonirritants	1.7%	0%	5.0%	0.1%
Type II Irritants	50%	87.9%	87.5%	50.0%
Type I Irritants	97.8%	100%	100%	99.9%