Table 2.
Scores for grading severity of ocular lesions
| Lesiona | Score |
|---|---|
| Cornea | |
| Scattered or diffuse areas of opacity (other than slight dulling of normal luster), details of iris clearly visible | 1 |
| Easily discernible translucent areas, details of iris slightly obscured | 2 |
| Opalescent areas, no details of iris visible, size of pupil barely discernible | 3 |
| Complete corneal opacity, iris not discernible | 4 |
| Iris | |
| Markedly deepened folds, congestion, swelling, moderate circumcorneal injection (any one of these or combination of any thereof), iris still reacting to light (sluggish reaction is positive) | 1 |
| No reaction to light, hemorrhage, gross destruction (any one or all of these) | 2 |
| Conjunctiva | |
| A. Redness (refers to palpebral and bulbar conjunctiva only) | |
| Some vessels definitely injected above normal | 1 |
| Diffuse, crimson red, individual vessels not easily discernible | 2 |
| Diffuse beefy red | 3 |
| B. Chemosis | |
| Any swelling above normal (includes nictitating membrane) | 1 |
| Obvious swelling with partial eversion of the lids | 2 |
| Swelling with lids about half closed | 3 |
| Swelling with lids about half closed to completely closed | 4 |
Table is adapted from the CPSC Illustrated Guide for Grading Eye Irritation Caused by Hazardous Substances, available by written request: Directorate for Epidemiology and Health Sciences, CPSC, Washington, DC 20207.
Scores in bold indicate positive responses. Scores of 0 are assigned for each parameter if the cornea, iris, or conjunctiva is normal.
a
Positive responses for individual animals are based on meeting or exceeding the minimum severity criteria for any one of the four types of eye injuries at any of the three time points.