Table 5.
Percentage of substances labeled as ocular irritants based on various population positive response rates (p) for the three strategies
| Population Positive Response Rate (p) | Percentage of Substances That Would be Labeled as Ocular Irritants | ||
|---|---|---|---|
| Strategy 1 Current FHSA | Strategy 2 ≥1/3 Positive Animals | Strategy 3 ≥2/3 Positive Animals | |
| 1.7%a | 0.0% | 5.0% | 0.1% |
| 5% | 0.2% | 14.3% | 0.8% |
| 10% | 2.7% | 27.1% | 2.8% |
| 20% | 20.4% | 48.8% | 10.4% |
| 30% | 48.2% | 65.7% | 21.6% |
| 33.3% | 57.2% | 70.4% | 25.9% |
| 40% | 72.6% | 78.4% | 35.2% |
| 50%a | 87.9% | 87.5% | 50.0% |
| 60% | 95.7% | 93.6% | 64.8% |
| 66.7% | 98.2% | 96.3% | 74.1% |
| 70% | 98.9% | 97.3% | 78.4% |
| 80% | 99.8% | 99.2% | 87.6% |
| 90% | 100% | 99.9% | 97.2% |
| 97.8%a | 100% | 100% | 99.9% |
| 100% | 100% | 100% | 100% |
a
Estimated underlying positive response rates for the NICEATM database (see Table 9)