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Prothrombin time (PT) was evaluated with fresh human plasma in the presence or absence of the control GPSPFPAC or active knob GPRPFPAC in non-PEGylated and PEGylated form. (A) PT values for plasma + HBS and GPSPFPAC and GPRPFPAC with and without 5 kDa PEG. (B) INR values for corresponding experimental and control groups. (Mean ± SD; n= 3; * denotes p < 0.01 and $ denotes p < 0.001).
