Table 3.
Mixture groupa | EC50-AQ
|
Slope-AQ
|
EC50-IQ
|
Slope-IQ
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
A:B | 15 min | 30 min | 45 min | 15 min | 30 min | 45 min | 15 min | 30 min | 45 min | 15 min | 30 min | 45 min |
Sham | ||||||||||||
EIAC:EIAC | 1.00 | 0.93 | 0.90 | 0.94 | 0.93 | 1.02 | 1.04 | 1.07 | 1.15 | 0.69 | 0.78 | 0.92 |
EBAC:EBAC | 1.02 | 1.05 | 1.00 | 0.91 | 1.02 | 1.01 | 1.14 | 1.31 | 1.42 | 0.72 | 0.89 | 0.97 |
ECAC:ECAC | 1.01 | 1.01 | 0.98 | 0.90 | 0.91 | 0.92 | 1.29 | 1.30 | 1.32 | 0.70 | 0.70 | 0.71 |
EFAC:EFAC | 0.94 | 1.00 | 1.02 | 0.70 | 0.86 | 1.01 | 1.31 | 1.46 | 1.56 | 0.61 | 0.72 | 0.83 |
3M2B:3M2B | 0.97 | 0.98 | 1.02 | 1.09 | 0.95 | 0.97 | 1.18 | 1.22 | 1.26 | 0.77 | 0.70 | 0.71 |
Full:full | ||||||||||||
EIAC:EBAC | 1.02 | 1.01 | 1.00 | 0.92 | 0.94 | 0.93 | 1.10 | 1.22 | 1.34 | 0.70 | 0.84 | 0.95 |
Full:high | ||||||||||||
EIAC:ECAC | 1.02 | 1.07 | 1.07 | 1.14 | 0.90 | 0.91 | 1.17 | 1.32 | 1.41 | 0.82 | 0.69 | 0.74 |
EBAC:ECAC | 1.07 | 1.09 | 1.08 | 0.84 | 0.85 | 0.86 | 1.26 | 1.37 | 1.49 | 0.64 | 0.65 | 0.70 |
Full:low | ||||||||||||
EIAC:EFAC | 1.12 | 1.26 | 1.54 | 0.81 | 0.76 | 0.92 | 1.42 | 1.80 | 2.28 | 0.64 | 0.64 | 0.76 |
EBAC:EFAC | 0.86 | 0.95 | 1.13 | 0.70 | 0.65 | 0.84 | 1.06 | 1.35 | 1.77 | 0.58 | 0.53 | 0.54 |
High:low | ||||||||||||
ECAC:EFAC | 0.82 | 0.83 | 0.84 | 0.69 | 0.64 | 0.59 | 1.06 | 1.20 | 1.32 | 0.57 | 0.51 | 0.49 |
SN2:NPN | ||||||||||||
EIAC:3M2B | 0.90 | 0.89 | 0.86 | 1.09 | 0.91 | 0.81 | 0.97 | 1.04 | 1.03 | 0.77 | 0.68 | 0.63 |
EBAC:3M2B | 0.91 | 0.86 | 0.87 | 1.14 | 0.97 | 0.87 | 0.98 | 1.02 | 1.08 | 0.83 | 0.71 | 0.65 |
ECAC:3M2B | 0.79 | 0.78 | 0.77 | 0.97 | 0.95 | 0.89 | 0.97 | 0.96 | 0.99 | 0.76 | 0.71 | 0.68 |
EFAC:3M2B | 0.87 | 0.86 | 0.88 | 0.81 | 0.64 | 0.55 | 1.07 | 1.12 | 1.18 | 0.57 | 0.48 | 0.40 |
Mixture group includes sham, SN2 agent TDT level (full, high, low TDT [see Table 2]), and SN2:NPN (nonpolar narcotic) categories, see Table 1 for chemical names. Values shown in bold are within the range of 0.90 to 1.10 and are consistent with dose-addition if AQ values or independence if IQ values