Fig. 3.

A molecular interaction map for the FcεRI model^22,23. A MIM illustrates molecules, reactions, and contingencies. A line that begins and ends with an arrowhead represents noncovalent binding, whereas a pair of parallel lines with no arrowheads represents covalent binding. An open circle indicates enzymatic catalysis, an open triangle indicates stimulation, and a jagged line indicates cleavage of a covalent bond. For additional information about MIM conventions, see Kohn et al.^66,68. The numbers 1–8 refer to sections of Appendix S1 (ESI). Annotation of this MIM is provided in Appendix S2. Note that this MIM is intended to be read using the combinatorial interpretation of MIM notations⁶⁶.