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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Biomaterials. 2011 Jul 31;32(31):8029–8039. doi: 10.1016/j.biomaterials.2011.07.021

Figure 1b. pH related solubility.

Figure 1b

pH related solubility of the AmB-PMA in water. AmB-PMA was dissolved in water for injection (pH 7.3) at 1 mg of AmB/ml. On centrifugation, the AmB-PMA remained in solution. The solution pH was then adjusted to 5. The clear solution went turbid and, when centrifuged at 1,800 rpm for 10 min, gave an orange-yellow precipitate. The orange-yellow pellet dissolved in DMSO thereby confirming that it was free AmB. The optical density of the supernatants was measured at 409 nm and the result expressed as the percentage water solubility of the AmB in AmB-PMA when the solubility at pH 7.3 was 100% (n = 6).