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Severe retinal abnormalities in chimeric Rb−/−;p107−/− embryos. Histological sections of eyes, stained with hematoxilyn–eosin. (A) Normal retina of a chimeric Rb+/−;p107−/− embryo (E17.5). (B) Dysplastic retina of a chimeric Rb−/−;p107−/− embryo (E17.5), with rosettes (C), and an increased number of pyknotic nuclei (D) indicative of apoptosis. Magnification (A,B) 100×; (C) 200×; (D) 400×.
