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. 1998 Jun 1;12(11):1599–1609. doi: 10.1101/gad.12.11.1599

Figure 7.

Figure 7

 Abnormal apoptosis during retinal development of chimeric Rb−/−;p107−/− mice. FITC staining of apoptotic retinal cells (TUNEL assay). (A) Normal level of apoptosis in chimeric Rb+/−;p107−/−;hIRBPp53DD embryo (E17.5). (B) Increased level of apoptosis in chimeric Rb−/−;p107−/− embryo (E17.5). (C) Normal level of apoptosis in wild-type C57Bl/6 neonate (P11). (D) Massive apoptosis in chimeric Rb−/−;p107−/− neonate (P11). (ONL) Outer nuclear layer; (INL) inner nuclear layer; (L) lens. Magnification (A–D) 200×.