Table 1.
Diagnostic and prognostic value of tear proteins assessed by agarose gel electrophoresis using automated system Hyrys–Hydrasys SEBIA
| High risk groups for DED | Biochemical markers in tear film | Diagnostic and prognostic value |
|---|---|---|
| Computer users | Lactoferrin, lysozyme | Differential diagnosis of excessive evaporation (normal level) and tear aqueous deficiency (decreased level) |
| Decreased lactoferrin level; Increased albumin level | Inflammatory reaction | |
| Decreased lactoferrin and lysozyme levels | Early diagnosis of DED | |
| Decreased level of lactoferrin <18% | Risk estimation for severe complications | |
| Normalized concentration of lactoferrin | Assessment of treatment efficacy | |
| Contact lens wearers | Lactoferrin, lysozyme | Differential diagnosis of excessive evaporation (normal level) and tear aqueous deficiency (decreased level) |
| Decreased lactoferrin level; Increased albumin level | Inflammatory reaction | |
| Decreased lysozyme level | High risk of infections | |
| Decreased lactoferrin and lysozyme levels; Increased albumin and lipocalins levels | Contact lens intolerance | |
| Normalized concentration of lactoferrin | Assessment of treatment efficacy |