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. Author manuscript; available in PMC: 2011 Sep 8.
Published in final edited form as: Int Immunol. 2010 Jun 29;22(8):651–660. doi: 10.1093/intimm/dxq049

Figure 5. Diagrams of potential mechanisms for PD-1/PD-L1 interactions.

Figure 5

(A and B) A schematic representation of the mechanism of PD-L1 binding to PD-1 and CD80 appears to involve significant and detectable conformational change. (C and D) A schematic representation of the mechanism of PD-L2 and CTLA-4 interact directly with PD-1 and CD80, respectively.