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. 2011 Aug 30;6(8):e24083. doi: 10.1371/journal.pone.0024083

Table 4. Outcome for the 297 women triaged only with HPV mRNA.

HPV mRNA result Outcome % % 95% CI
CIN2+ 1) <CIN2 2) Total 3) Sensitivity 94.2 88.7, 99.7
Positive 65 32 97 Specificity 86.0 81.5, 90.5
Negative 4 196 200 PPV 67.0 57.7, 76.4
Total 69 228 297 NPV 98.0 96.1, 99.9

Number of women found with high grade lesion (CIN2+) and number of women referred back to the screening program (<CIN2).

1)

Prevalence CIN2+ 23.2% (95% CI, 18.4, 28.0).

2)

<CIN2 includes women with a histological diagnosis of CIN1 or CIN0 (n = 53) and women referred back to screening because of two normal follow-up smears 12 months apart or one normal LBC and a negative HPV result (n = 175).

3)

Chi square  =  151.2, p<0.001.