Table 4. Outcome for the 297 women triaged only with HPV mRNA.
HPV mRNA result | Outcome | % | % | 95% CI | ||
CIN2+ 1) | <CIN2 2) | Total 3) | Sensitivity | 94.2 | 88.7, 99.7 | |
Positive | 65 | 32 | 97 | Specificity | 86.0 | 81.5, 90.5 |
Negative | 4 | 196 | 200 | PPV | 67.0 | 57.7, 76.4 |
Total | 69 | 228 | 297 | NPV | 98.0 | 96.1, 99.9 |
Number of women found with high grade lesion (CIN2+) and number of women referred back to the screening program (<CIN2).
Prevalence CIN2+ 23.2% (95% CI, 18.4, 28.0).
<CIN2 includes women with a histological diagnosis of CIN1 or CIN0 (n = 53) and women referred back to screening because of two normal follow-up smears 12 months apart or one normal LBC and a negative HPV result (n = 175).
Chi square = 151.2, p<0.001.