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. 2011 Aug 30;6(8):e24226. doi: 10.1371/journal.pone.0024226

Figure 5. Helios is associated with an activated non-mature phenotype in suppression assays.

Figure 5

After suppression assays (1/2 Treg/responder ratio), human CD4+ Teffs (A) and Tregs (B) were divided into 4 subsets according to Helios and Foxp3 co-expression. Helios+Foxp3- cells had the least mature and the most activated phenotypes in human CD4+ Teffs (A) and Tregs (B) in suppression assays, while Foxp3 expressing cells were enriched for mature CD45RO+ CD45RA- subsets. Data are representative of 2 experiments.