Table 3. Helios expression, FOXP3 demethylation, maturation phenotype and Treg suppressive function.
Patient, linical data | % Helios expression | % Unmethylated FOXP3 in TSDR | Suppressive function, AUC | % CD31 expression | % CD45RA+ D45RO-expression | % CD45RO+ D45RA-expression | ||
CD4+ esponders | CD8+ esponders | |||||||
Male, 57 yrs, alcoholic liver disease | 1 wk post Tx | 74 | 66 | 139 | 97 | 12 | 17 | 22 |
3 mths post Tx | 57 | 46 | 105 | 0 | 22 | 27 | 21 | |
Female, 59 yrs,Primary biliary cirrhosis | 1 wk post Tx | 74 | 42 | 14 | 5 | 8 | 7 | 88 |
3 mths post Tx | 64 | 50 | 35 | 39 | 17 | 7 | 82 | |
Healthy donor, male, 25-40 yrs | 72 | 76 | 204 | No data | 9 | 27 | 65 |