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. 2000 Sep 1;14(17):2161–2172. doi: 10.1101/gad.814700

Figure 7.

Figure 7

Model for pal-1 regulation. In wild type, the intronic factor I allows a preinitiation complex containing SOP-1 to transcribe pal-1. The holoenzyme, consisting of the Mediator complex and PolII-core polymerase complex are brought to the promoter through the action of other factors, here represented by factor II. Such factors, together with the general A/P specifying factors BAR-1 and POP-1, are prevented by SOP-1 from activating transcription in the absence of factor I. In a pal-1(e2091); sop-1(−) background, the negative effect of SOP-1 is reduced, allowing pal-1 transcription. The bx92, bx93, and bx107 mutations reduce or eliminate the carboxy-terminal glutamaine-rich domain of SOP-1, implicating this domain in the SOP-1-mediated repression.