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. Author manuscript; available in PMC: 2012 Oct 18.
Published in final edited form as: Acc Chem Res. 2011 Apr 29;44(10):914–924. doi: 10.1021/ar200061q

FIGURE 9.

FIGURE 9

(A) A schematic of the dual probe that could be activated by an enzyme. The probe is composed of a AuNC and fluorescent dyes linked together through a peptides cleavable by an enzyme. (B) Percentage increase in fluorescence intensity as a function of MMP-2 activity (20 fmol FITC-GKGPLGVRGC-AuNCs, incubation time: 12 h); (C) Fluorescence images of FITC-GKGPLGVRGC-AuNCs after incubation with different concentrations of MMP-2 at 37 °C for 12 h. The sample was mixed with 1.5% agarose to form gel for imaging.35