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Model for RPL-12 feedback regulation. Productively spliced mRNA encodes for RPL-12. When present in excess, RPL-12 either positively or negatively regulates splicing of its own pre-mRNA, as shown. This reduces the level of productively spliced mRNA and increases the level of unproductively spliced mRNA. The unproductively spliced mRNA is subsequently eliminated by mRNA surveillance.
