Table 4.
Autoimmune disease | No. of patients | MSC source | Delivery route | Clinical outcome | Reference |
---|---|---|---|---|---|
Multiple sclerosis | 10 | Allogeneic bone marrow | Intrathecal | Mixed | Mohyeddin et al.9 |
Scleroderma | 1 | Allogeneic bone marrow | i.v. | Improved | Christopeit et al.10 |
Multiple sclerosis | 1 | Allogeneic umbilical cord | i.v. | Improved | Liang et al.11 |
Multiple sclerosis | 3 | Mixed allo & autologous fat | Mixed i.v. & Intrathecal | Improved clinic MRI unchanged | Riordan et al.12 |
Crohns fistulae | 14 | Autologous fat | Intrafistula | 71 % closure | Garcia-Olmo et al.13 |
Scleroderma digital ulcus | 2 | Autologous blood & bone marrow | Local | Improved | Nevskaya et al.14 |
Lupus nephritis | 15 | Allogeneic bone marrow | i.v. | Improved SLEDAI and proteinuria | Liang et al.15 |
Lupus nephritis | 16 | Allogeneic umbilical cord | i.v. | Improved SLEDAI and proteinuria | Sun et al.16 |
SLE | 2 | Autologous bone marrow | i.v. | No change | Carrion et al.17 |
SLE alveolar hemorrhage | 1 | Allogeneic umbilical cord | i.v. | Improved | Liang et al.18 |
Crohns disease | 10 | Autologous bone marrow | IVI | Improved | Duijvestein et al.19 |
Multiple sclerosis | 15 | Autologous bone marrow | Intrathecal (all) plus IVI (5) | Some stabilized | Karussis et al.20 |
Amyothrophic lateral sclerosis | 19 | Autologous bone marrow | Intrathecal (all) plus i.v. (9) | No change | Karussis et al.20 |
Multiple sclerosis | 10 | Autologous bone marrow | Intrathecal | Mixed | Yamout et al.21 |
SLE, systemic lupus erythematosus.