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Inhibition Constants of PLCβ3 Variants Measured by FCPIA
| Variant | KI ± SEM (nM) (n)a |
|---|---|
| PLCβ3 (wt)b | 6.0 ± 1. (5) |
| -F715A | 2.0 ± 0.3 (4) |
| -L876A | 3.1 ± 0.5 (4) |
| -L879A | 1.6 ± 0.1 (3) |
| PLCβ3-Δ892 (wt)b | 270 ± 60 (4) |
| -F715Ab | 31 ± 6 (3) |
| -AAAc | 26 ± 6 (3) |
| PLCβ3-Δ847 (wt)b | NBd (3) |
Number (n) of independent experiments performed in duplicate.
Includes samples from at least two independent protein purifications.
R872A L876A L879A
No binding detected.
