Figure 2.

TRAIL is required for efficient APAP-induced liver damage in vivo. Wild type (WT) or TRAIL-deficient mice (TRAIL−/−) were treated with PBS as control or APAP (400 mg/kg body weight), and liver damage was analyzed by histology (a) and transaminase levels (AST) in serum (b) after 5 h. Pooled experimental data from 8 to 12 mice per group are shown