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Bim is required for efficient APAP-induced liver damage in vivo. Wild-type (WT) or Bim-deficient mice (Bim−/−) were treated with PBS as control or 400 mg/kg body weight APAP, and liver damage was analyzed by histology (a) and transaminase levels (AST) in serum (b). Pooled data from 10 to 12 mice per group are shown. **P=0.0047 (unpaired Student's t-test)
