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. 1998 Jun 15;12(12):1775–1780. doi: 10.1101/gad.12.12.1775

Figure 5.

Figure 5

Figure 5

 Role of mSiah2-directed proteasomal degradation of N-CoR in nuclear receptor repression in N18 cells. (A) RevErb is a potent repressor in 293T but not in N18 cells. (B) MG132 increases N-CoR protein expression in N18 cells. Western blot performed as in Fig. 4. (C) Effects of MG132 on repression. (Left) MG132 increases RevErb repression in N18 cells; (right) TR represses in N18 cells, and MG132 potentiates TR repression. (D) mSiah2ΔN cotransfection increases RevErb repression in N18 cells. Three micrograms of mSiah2ΔN expression plasmid was transfected.