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. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Biochem J. 2011 Apr 15;435(2):327–336. doi: 10.1042/BJ20102118

Figure 7. Effects of DEA on synaptic activity.

Figure 7

(A) sPSCs, including Glu-sPSC and GABA-sPSC components, in hippocampal neurons cultured with or without 0.1 µM DEA for 10 days. DEA-supplemented neurons exhibited increased frequency of sPSCs. The frequency of sPSCs in unsupplemented control neurons was decreased significantly by bicuculline, whereas NBQX/APV decreased the frequency in the DEA-supplemented neurons. Upper panel: representative sPSC traces obtained from control and DEA-treated neurons. Paired Student’s t tests were performed against the baseline value of each group (##P < 0.01, ###P < 0.001) or between indicated groups (***P < 0.001). (B) sPSCs in hippocampal neurons supplemented with 1 µM DHA or 0.1 µM DEA for 10 days. Paired Student’s t tests were performed against the control value (**P < 0.01, ***P < 0.001). (C) No effects of acute application of DHA or DEA on synaptic activity. Error bars represent S.E.M. (n = 5). The data represent three independent experiments. N.S., not significant.