Figure 2.

Rip1/Ipf1^▴ mice show abnormal islet composition. (A) The distribution of insulin (Ins⁺)-, IAPP (IAPP⁺)-, or glucagon (Glu⁺)-expressing cells per total number of islet cells in wild-type and Rip1/Ipf1 mice. (B) Ratio of Ins⁺ to IAPP⁺ cells in islets from wild-type and Rip1/Ipf1 mice. (Open area) Ins⁺ only; (solid area) IAPP⁺ only; (shaded area) Ins⁺ and IAPP⁺ coexpressed. (C) Ratio of Ins⁺ to Glu⁺ cells in islets from wild-type and Rip1/Ipf1 mice. (Open area) Ins⁺ only; (solid area) Glu⁺ only; (shaded area) Ins⁺ and Glu⁺ coexpressed. (A–C) n = 600–1050 cells.