Fig. 1.

Notch1 and RBPJ binding sites in human TLL cells. (A) Distribution and overlap of RBPJ and Notch1 binding peaks in CUTLL1 cells. Promoter regions are defined as sequences within 2 kb of the TSS of annotated genes. (B) Notch1 and RBPJ ChIP-Seq signals (expressed as reads per kilobase per million aligned reads, RPKM) at Notch1-only sites, RBPJ-only sites, and RBPJ/Notch1 cosites. (C) Enriched transcription factor motifs lying ±250 bp of Notch1 and RBPJ binding sites. A RBPJ consensus motif embedded within the extended ZNF143 motif is boxed.