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. 1998 Jun 15;12(12):1917–1928. doi: 10.1101/gad.12.12.1917

Figure 6.

Figure 6

 C/EBPα mRNA is expressed throughout development of the murine mammary gland. C/EBPα mRNA is detected during all stages of mammary development including in the mature virgin (vir), and during mid-pregnancy (13-P), late pregnancy (17-P), day 1 lactation (1-L), and mid-lactation (8-L). The expression of C/EBPα mRNA in the mammary gland is ∼20%–25% the level of C/EBPα detected in the mature rat liver (liver). When corrected for the increase of epithelial cells that occurs during development of the mammary gland, measured by the levels of K18 mRNA, the ratio of C/EBPα/K18 remains fairly constant during development. The ratio of C/EBPα/K18 at day 1 lactation (0.20) is not significantly different from that observed during mid-pregnancy (0.30) or late pregnancy (0.24). The apparent decrease in both C/EBPα and K18 that occurs at mid-lactation (8-L) is most likely a dilutional effect of the abundant milk protein mRNAs.