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. 2011 Aug 24;108(36):14715–14716. doi: 10.1073/pnas.1110570108

Fig. 1.

Fig. 1.

(A) Working model of ZNF143-Notch/RBPJ crosstalk. ZNF143 occupies DNA sites that overlap with RBPJ elements. When ZNF143 is bound, RBPJ is not. When ZNF143 dissociates, sites can be occupied by RBPJ-only complexes, which may contain corepressors SMRT and SKIP, required for RBPJ targeting to the nucleus (2). Both ZNF143 and RBPJ-only occupancy is predominantly associated with transcriptional repression. In the presence of active Notch, Notch/RBPJ/MAML complexes form. These recruit p300 and other coactivators and are predominantly associated with transcriptional activation. (B) Working model of EBF-EBNA2/RBPJ crosstalk. EBF consensus binding sites contain embedded high-affinity RBPJ sites. The same sites are likely used by EBF dimers or RBPJ at different times. EBNA2/RBPJ complexes can bind DNA after EBF dimer dissociation, or EBF monomer could cobind with RBPJ/EBNA2 complexes. These sites are generally associated with markers of transcriptional activity. EBNA-LP is a coactivator protein recruited by the C-terminal acidic domain of EBNA2 (19).