Table 2.
Tag-SNPs associated with risk of meningioma at p-trend<0.01 in hospital-based case-control study of meningioma, National Cancer Institute Adult Brain Tumor Study, 1994–1998
| Region Gene | SNP ID | Genotype | Control n (%) | Case n (%) | Odds Ratio (OR) | (95% CI) |
|---|---|---|---|---|---|---|
| NFKB1 | ||||||
| NFKB1 | rs230540 | TT | 126 (38.3) | 49 (48.5) | 1.00 | |
| CT | 162 (49.2) | 48 (47.5) | 0.67 | (0.41 – 1.11) | ||
| CC | 41 (12.5) | 4 (4.0) | 0.16 | (0.05 – 0.51) | ||
| Ptrend | 0.001 | |||||
| rs3755867 | AA | 140 (42.4) | 52 (51.5) | 1.00 | ||
| AG | 156 (47.3) | 47 (46.5) | 0.74 | (0.45 – 1.22) | ||
| GG | 34 (10.3) | 2 (2.0) | 0.11 | (0.02 – 0.48) | ||
| Ptrend | 0.002 | |||||
| rs1585213 | CC | 117 (35.6) | 42 (41.6) | 1.00 | ||
| CT | 164 (49.9) | 55 (54.5) | 0.86 | (0.52 – 1.42) | ||
| TT | 48 (14.6) | 4 (4.0) | 0.16 | (0.05 – 0.50) | ||
| Ptrend | 0.004 | |||||
| VCAM1 | ||||||
| VCAM1 | rs2209627 | AA | 222 (67.7) | 54 (53.5) | 1.00 | |
| AG | 92 (28.1) | 41 (40.6) | 2.60 | (1.53 – 4.42) | ||
| GG | 14 (4.3) | 6 (5.9) | 2.13 | (0.66 – 6.80) | ||
| Ptrend | 0.001 | |||||
| FCER1G | ||||||
| NDUFS2 | rs4656993 | GG | 116 (35.3) | 21 (20.8) | 1.00 | |
| AG | 155 (47.1) | 50 (49.5) | 1.98 | (1.08 – 3.61) | ||
| AA | 58 (17.6) | 30 (29.7) | 2.92 | (1.45 – 5.87) | ||
| Ptrend | 0.002 | |||||
| FCER1G | rs12094497 | GG | 270 (82.1) | 93 (92.1) | 1.00 | |
| AG | 52 (15.8) | 8 (7.9) | 0.34 | (0.17 – 0.87) | ||
| AA | 7 (2.1) | 0 (0.0) | 0.00 | 0 | | ||
| Ptrend | 0.004 | |||||
| rs11587213 | AA | 224 (67.9) | 80 (80.0) | 1.00 | ||
| AG | 93 (28.2) | 19 (19.0) | 0.53 | (0.29 – 0.96) | ||
| GG | 13 (3.9) | 1 (1.0) | 0.20 | (0.02 – 1.72) | ||
| Ptrend | 0.008 | |||||
| CD14 | ||||||
| PRO1580 | rs3822356 | AA | 208 (63.4) | 49 (48.5) | 1.00 | |
| 1.09 | ||||||
| AG | (33.2) | 47 (46.5) | 2.24 | (1.34 – 3.76) | ||
| GG | 11 (3.4) | 5 (5.0) | 2.15 | (0.65 – 7.14) | ||
| Ptrend | 0.003 | |||||
| TNFRSF18 | ||||||
| TNFRSF18 | rs9729550 | AA | 180 (54.9) | 68 (67.3) | 1.00 | |
| AC | 121 (36.9) | 29 (28.7) | 0.56 | (0.33 – 0.95) | ||
| CC | 27 (8.2) | 4 (4.0) | 0.28 | (0.09 – 0.89) | ||
| Ptrend | 0.003 | |||||
| RAC2 | ||||||
| RAC2 | rs2213430 | CC | 103 (31.2) | 38 (37.6) | 1.00 | |
| CT | 165 (50.0) | 49 (48.5) | 0.56 | (0.32 – 0.96) | ||
| TT | 62 (18.8) | 14 (13.9) | 0.35 | (0.16 – 0.75) | ||
| Ptrend | 0.004 | |||||
| XDH | ||||||
| XDH | rs207444 | GG | 291 (88.5) | 97 (96.0) | 1.00 | |
| AG | 37 (11.3) | 4 (4.0) | 0.26 | (0.09 – 0.79) | ||
| AA | 1 (0.3) | 0 (0.0) | 0.00 | 0 | | ||
| Ptrend | 0.005 | |||||
| C1D | ||||||
| C1D | rs10203061 | AA | 235 (71.7) | 56 (56.0) | 1.00 | |
| AG | 85 (25.9) | 40 (40.0) | 1.98 | (1.18 – 3.33) | ||
| GG | 8 (2.4) | 4 (4.0) | 2.81 | (0.70 – 11.2) | ||
| Ptrend | 0.006 | |||||
| CCR6 | ||||||
| CCR6 | rs9459883 | GG | 265 (80.3) | 91 (90.1) | 1.00 | |
| CG | 63 (19.1) | 10 (9.9) | 0.42 | (0.20 – 0.89) | ||
| CC | 2 (0.6) | 0 (0.0) | 0.00 | 0 | | ||
| Ptrend | 0.008 | |||||
| rs3798315 | CC | 251 (76.1) | 87 (86.1) | 1.00 | ||
| CT | 72 (21.8) | 13 (12.9) | 0.43 | (0.21 – 0.87) | ||
| TT | 7 (2.1) | 1 (1.0) | 0.31 | (0.03 – 2.81) | ||
| Ptrend | 0.008 | |||||
| TLR1/TLR10/TLR6 | ||||||
| TLR10 | rs11466657 | AA | 306 (93.9) | 97 (98.0) | 1.00 | |
| AG | 20 (6.1) | 2(2.0) | 0.19 | (0.04 – 0.84) | ||
| GG | -- | -- | ||||
| Ptrend | 0.008 | |||||
| NOS1 | ||||||
| NOS1 | rs10850803 | AA | 273 (83.2) | 73 (72.3) | 1.00 | |
| AG | 54 (16.5) | 24 (23.8) | 1.70 | (0.92 – 3.13) | ||
| GG | 1 (0.3) | 4 (4.0) | 13.50 | (1.16 – 157) | ||
| Ptrend | 0.009 | |||||
| DEFA5 | ||||||
| DEFA5 | rs10503360 | TT | 95 (28.8) | 13 (12.9) | 1.00 | |
| GT | 160 (48.5) | 56 (55.5) | 2.10 | (1.05 – 4.19) | ||
| GG | 75 (22.7) | 32 (31.7) | 2.74 | (1.28 – 5.83) | ||
| Ptrend | 0.01 | |||||
1
Odds ratios adjusted for sex, age, study hospital, and distance of residence from hospital.