Figure 9.

TRIP8b^−/− mice do not exhibit gross behavioral abnormalities. A, Locomotor activity. Data represent the number of photobeam breaks during 5 min bins. B, Grooming behavior. Data represent the total time spent grooming (left bars and y-axis) and the total number of individual grooming bouts (right bars and y-axis) during a 10 min period of observation. C, Social interaction with a juvenile (social learning). Experimental mice were placed in a novel cage with a juvenile mouse for 2 min (initial), and the test was repeated 3 d later (recognition) (^###p < 0.001 compared with “initial,” planned comparisons, contrast analysis). D, Social interaction with a caged conspecific. Data represent the time spent interacting with an empty cage (inanimate target) or with a caged sex-matched conspecific (social target). ^#p < 0.05, ^###p < 0.001 compared with the inanimate target, planned comparisons, contrast analysis. E, Sucrose preference test. Data represent the percentage of the total daily volume of liquid (sucrose or water) consumed that was consumed from the sucrose bottle (volume of sucrose solution consumed/total volume consumed). The dotted line represents chance performance. All data are from 19 littermate pairs.