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. Author manuscript; available in PMC: 2011 Sep 8.
Published in final edited form as: Brain Res. 2010 May 10;1345:1–8. doi: 10.1016/j.brainres.2010.05.009

Figure 2.

Figure 2

Current-voltage (I–V) study in a single hypoglossal motoneuron in control and serotonin-containing solutions. A family of hyperpolarizing command voltage pulses (10mV increments) were applied from a holding potential of –50 mV. A. Control solution containing CNQX, AP-5 and bicuculline. B. Solution containing serotonin (5 µM) in addition to CNQX, AP-5 and bicuculline. Note the downward shift of the holding current when a serotonin-containing solution was employed (I hold). C. Instantaneous I–V relationship, open circles = control, filled circles = serotonin. Note the decrease in conductance in the solution containing serotonin. The equilibrium potential of the inward current that is induced by serotonin was −92 mV, which was the potassium equilibrium potential calculated for these cells. D. Steady-state I–V relationship (circles as in C), showing that the inward rectification is increased by serotonin. E. Serotonin-induced currents. Plot represents the differences in instantaneous (open circles) and steady-state (filled circles) currents between control and serotonin-containing solutions.