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. Author manuscript; available in PMC: 2012 Jul 6.
Published in final edited form as: Cell Metab. 2011 Jul 6;14(1):67–79. doi: 10.1016/j.cmet.2011.04.013

Figure 2. Smad3 deficiency suppresses white adipose tissue differentiation.

Figure 2

a, WT and KO mice intake similar caloric energy as monitored by weekly food intake. b, c, RD-fed or HFD-fed KO mice, harbor reduced fat mass (b) and triglyceride levels (c). d, e, KO adipocytes (red) on a RD (open symbols) or HFD (closed symbols) maintain smaller size compared to WT adipocytes (black). f, g, KO mice fed RD or HFD exhibit significantly reduced levels of inflammatory M1-macrophage specific transcripts (f) and increased levels of protective M2-macrophage specific transcripts (g). *p < 0.05; **, p< 0.005; ***, p<0.001.