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Comparison of the S. cerevisiae THI20 N-terminal domain with S. typhimurium ThiD (PDB entry 1jxh). Both structures are shown as ribbon diagrams with helices colored red, β-strands colored yellow and loop regions colored green. The active site in the model of S. typhimurium ThiD is indicated by a space-filling model of HMP (C atoms colored green, O atoms colored red and N atoms colored blue).
