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Nocodazole-treated day 3.5+ 1 embryos from heterozygous crosses. (A) A normal embryo, showing regular-sized nuclei and many arrested metaphases (some examples indicated by arrows). (B) A similarly treated null embryo, showing irregularly sized nuclei, very few metaphases (arrow), and a large number of micronuclei (selected examples shown by arrowheads). Scale bars represent 50 μm.
