Table 3. Percentage identity matrix for DHFR (bottom left) and TS (top right) enzymes among species.

Asterisks (*) denote bifunctional DHFR-TS. Calculated after alignment using ClustalX 2.0.10 (Larkin et al., 2007 ▶).

	C. hominis*	P. falciparum*	B. bovis*	T. cruzi*	L. major*	T. gondii*	H. sapiens	S. aureus	L. casei	E. coli
Cryptosporidium hominis*		54	57	55	54	55	57	47	50	50
Plasmodium falciparum*	31		63	52	54	61	56	46	46	48
Babesia bovis*	40	33		51	53	53	56	48	49	48
Trypanosoma cruzi*	35	29	27		80	59	63	47	48	50
Leishmania major*	33	25	24	53		59	61	49	49	49
Toxoplasma gondii*	43	28	35	32	32		66	45	45	47
Homo sapiens	35	31	33	31	29	37		49	50	54
Staphylococcus aureus	31	28	33	25	23	27	28		30	60
Lactobacillus casei	25	23	25	22	22	26	24	64		60
Escherichia coli	33	28	34	33	30	36	29	41	29