Table 2.
Effects of activation of CRF2 receptors on cardiovascular functions in animal models
| Site of injection | Species | Effect | Reference |
|---|---|---|---|
| icv | Rat | ↑ Heart Rate | 141 |
| Rat | ↑ Mean arterial pressure | 141 | |
| Rat | ↑ Cardiac output | 141 | |
| iv | Dog | Vasodilation | 171 |
| Dog | ↓ Blood pressure | 171 | |
| Dog | ↑ Heart Rate | 171 | |
| In vitro | Rat | ↑ Coronary blood flow | 146 |
| Rat | Vasodilation | 146 | |
| Rat | ↑ Aortic pressure | 146 | |
| Rat | ↑ Oxygen consumption | 146 | |
| Rat | Positive inotropic effect | 146 | |
| Rat | ↑ Atrial natriuretic peptide | 145 |
↑
increase; ↓, decrease; icv, intracerebroventricular; iv, intravenous