Figure 1.

Overview of the analysis approach to investigate interactions between pathways. A: Information from different resources and experimental data is integrated into a weighted gene/protein interaction network and a set of pathways and their associated genes and proteins. B: Based on the interaction network, an interaction score and significance is calculated for each pathway pair. C: Example of the process of identifying a set of non-redundant shortest paths for the interaction of pathway P1 to P2. This panel shows step 5-7 of the calculation as described in the Methods section. D: Two representations of the resulting pathway interactions. The top panel shows the pathway interaction network, where each edge represents a significant interaction between two pathways. The bottom panel shows a detailed network showing the identified shortest paths between pathways P1, P4 and P2.